Biomolecular Chemistrya-hatano.html
Hatano Laboratorya-hatano.html
Department of  Chemistry, Shibaura Institute of Technologyhttp://www.shibaura-it.ac.jp/
 
Mein Contents

Home


Research Projects


Research Articles


Members


研究室の風景


Biomolecules


研究室ファイル


サッカー部


生体分子化学研究室


 本研究室では、有機合成化学的な手法と生化学的な手法を組み合わせて、新しいバイオテクノロジーを目指しています。生体分子はそれだけでも機能を有しています。しかし、ちょっとした変換によって更なる機能の飛躍が目指せるのです。

| DNA | Enzyme | Protein |

上記の三つの生体分子、生体高分子を利用して、面白い機能の発現を目指しています。


Copyright (C) 2008 Shibaura Institute of Technology. All Rights Reserved.

 

工学部共通学群(化学)生体分子化学研究室

  [ 研究論文 ] ・・・27 報 (First: 15 報、2015. 9 現在)

査読論文教育論文  | 総説 | プロシーディングス  |  執筆物特許

| 学会発表 No. 1学会発表 No. 2学会発表 No. 3 |

競争的外部資金社会的外部活動  |  学外委員


27 A. Hatano, M.Shiraishi, N. Terado, A. Tanabe, K. Fukuda, Enzymatic synthesis and RNA interference of nucleosides incorporating stable isotopes into a base moiety,

Bioorganic & Medicinal Chemistry, 2015, 11, 6683-6688. doi:10.1016/j.bmc.2015.09.011











26 A. Hatano, M.Okada, K. Dezaki, S. Hirai, Improved synthesis of mercapto C-nucleoside possessing p-phenyl thiol as base using a lithiated coupling reaction, Tetrahedron, 2015,70,1095-1100. doi:10.1016/j.tet.2014.12.085











25 A. Hatano, M. Kurosu, S. Yonaha, M. Okada, S. Uehara, One-pot approach to functional nucleosides possessing fluorescent group using nucleobase-exchange reaction by thymidine phosphorylase, Organic & Biomolecular Chemistry, 2013, 11, 6900-6905. Inside Cover Picture. DOI:10.1039/C3OB41605D


24 A. Hatano, M. Okada, G. Kawai, Solution structure of S-DNA formed by covalent base pairing involving a disulfide bond, Organic & Biomolecular Chemistry, 10, 7327-7333, 2012. DOI:10.1039/C2OB25346A.
















23 A. Hatano, M. Okada, K. Shimazaki, S. Uehara, Y. Ishikawa, A. Matsumoto, Y. Fujita, M. Nishimura, Inhibitory effect on microbial growth using the benzyl phenyl sulfide, Biocontrol Science, 16, 63-67, 2011.


22 A. Hatano, M. Nishimura, I. Souta, Impact of Unnatural Nucleosides on The Control of Microbial Growth, Biocontrol Science, 14, 55-60, 2009.

 

21 A. Hatano, A. Harano, Y. Takigawa, Y. Naramoto, K. Toda, Y. Nakagomi, H. Yamada, Kinetic Parameters and Recognition of Thymidine Analogues Substituted the Functional Group by Thymidine Phophorylase, Bioorganic & Medicinal Chemistry, 16, 3866–3870, 2008.


20 M. Kirihara, Y. Asai, S. Ogawa, T. Noguchi, A. Hatano, Y. Hirai, A mild and environmentally benign oxidation of thiols to disulfides, Synthesis, 21, 3286-3289, 2007. 


19 M. Kirihara,Y. Uchiyama, A.  Harano, N. Inoue, R. Takizawa, A. Hatano, The reaction of acylanion equivalents with 3-bromo-3,3-difluoropropene: facial synthesis of 1-aryl-4,4-difluorobut-3-en-1-ols, ITE Letters on Batteries, New Technologies & Medicine 7, 589-592, 2006. 


 

18 M. Kirihara, S. Ogawa, T. Noguchi, K. Okubo, Y. Monma, I. Shimizu, R. Shimosaki, A. Hatano, and Y. Hirai, Chemoselective Bromination of Active Methylene and Methyne Compounds by Potassium Bromide, Hydrochloric Acid and Hydrogen Peroxide, SYNLETT, 2006, 14, 2287-2289.

 

17 M. Kirihara, T. Noguchi, H. Kakuda, T. Akimoto, A.Shimajiri, M. Morishita, A. Hatano and Y. Hirai, Reaction of tertiary cyclopropyl silyl ethers with diethylaminosulfur trifluoride. Part 2: The Friedel-Crafts allylation and cyclopropylation of electron-rich aromatic compounds, Tetrahedron Letters, 2006, 47, 3777-3780.

 

16 A. Hatano, A. Harano, M. Kirihara, Importance of 3' Hydroxyl Group of the Nucleosides for the Reactivity of Thymidine Phosphorylase from Escherichia coli , Chemistry Letters, 2006, 35, 232.

 

15 M. Kirihara, K. Fujishita, N. Inoue, A. Hatano, Fluorination of Vinylsilanes Obtained by the trancs-Allylsilylation of Alkynes, ITE Lett., 2005, 6, 449-451.

 

14 M. Kirihara, H. Kakuda, M. Ichinose, Y. Ochiai, S. Takizawa, A. Mokuya, K. Okubo, A. Hatano and M. Shiro, Fragmentation of tertiary cyclopropanol compounds catalyzed by vanadyl acetylacetonate, Tetrahedron, 2005, 61, 4831-4839.

 

13 M. Kirihara, A. Harano, H. Tsukiji, R. Takizawa, T. Uchiyama, A. Hatano, Deprotection of dithioacetals using the tantalum(V) chrolide catalyzed oxidation of iodide ion by hydrogen peroxide, Tetrahedron Letters, 2005, 46, 6377-6380.

 

12 A. Hatano, S. Makita,and M. Kirihara, Synthesis and Redox-Active Base-pairing Properties of DNA incorporating Mercapto C-nucleosides, Tetrahedron, 2005, 61, 1723-1730.

 

11 M. Kirihara, K. Okubo, T. Uchiyama, Y. Ochiai, S. Matushima, A. Hatano, K. Kanamori, Aerobic oxidation of thiols to disulfides catalyzed by trichlorooxyvanadium, Chem. Pharm. Bull, 2004, 52, 625-627.

 

10 M. Kirihara, Y. Torii, K. Sato, R. Takizawa, A. Hatano, Aerobic oxidation catalyzed by polymer-supported vanadium compounds, ITE Lett., 2004, 5, 479-482.

 

9 M Kirihara, K Ookubo, T Koshiyama, Y Kato, A Hatano, Electrophilic Brominations of Organic Compounds by Employing Tantalum(V) Catalyzed Oxidation of Bromide Ion by Hydrogen Peroxide, ITE Lett., 2004, 5, 279-281.

 

8 A. Hatano, S. Makita and M. Kirihara, Synthesis and Characterization of a DNA Analogue Stabilized by Mercapto C-Nucleoside Induced Disulfide Bonding, Bioorganic & Medicinal Chemistry Letters. 2004, 10, 2459-2462.

 

7  M. Kirihara, H. Kakuda, M. Tsunooka, A. Shimajiri, T. Takuwa, A. Hatano, Reaction of tertiary cyclopropyl silyl ethers with diethylaminosulfur trifluoride: the effects of substituents on the cleavage of the cyclopropane ring, Tetrahedron Lett., 2003, 44, 8513-8518.

 

6  A. Hatano, M. Morikawa, M. Kirihara and Y. Okumura, Nematic ordering behavior in stretched fiber of a lipid-poly L-glutamic acid complex, ITE Lett., 2003, 4, 220-223.

 

5 M. Kirihara, T. Katou, and A. Hatano, Fe(acac)3 catalyzed trimethylsilylation of alcohols with trimethylsilyl azide, ITE Lett., 2002, 3, 225-227 .

 

4 A. Hatano, K. Tanaka, M. Shiro, and M. Shionoya, Syntheses of nucleic acid mimics designed for metal-induced strand formation on DNA, Tetrahedron, 2002, 58, 2965.

 

3 A. Hatano, K. Tanaka, M. Shiro, and M. Shionoya, Self-Assembly of Chelator-Type Nucleic Acid Mimics into a Single-Stranded ZnII Coordination Polymer, Chem. Lett., 2000, 822.

 

2 A. Hatano, H. Morishita, K. Tanaka, and M. Shionoya, Metal-Assisted Formation of Artificial Nucleic Acids, Nucleic Acids Symp.Ser., 1998, 39, 171.

 

1 Y. Okahata, A. Hatano, and K. Ijiro, Enhancing Enantioselectivity of a Lipid-coated Lipase via Imprinted Methods for Esterification in Organic Solvents, Tetrahedron: Asymmetry, 1995, 6, 1311.

 
Made on a Mac